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Sel'kov Model


The Sel'kov model is a planar dynamical system for self-sustained oscillations in glycolysis (Sel'kov 1968). A reduced form with a basal reaction term is

x^'=(a+x^2)y-x
(1)
y^'=b-(a+x^2)y,
(2)

where primes denote derivatives of x(t) and y(t) with respect to time t, and a and b are positive parameters (Das and Acharyya 2021). At a=0, the substitutions u=by, v=x/b, and tau=b^2t recover Sel'kov's limiting system for reaction exponent 2.

For a,b>0, the unique equilibrium point is (b,b/(a+b^2)). The Jacobian matrix there has determinant a+b^2 and trace 2b^2/(a+b^2)-1-a-b^2. A negative trace gives an attracting equilibrium point. If the trace is positive, the equilibrium point repels, and there is a periodic orbit in the positive quadrant. Indeed, the vector field points inward on the boundary away from the origin, y^'<=b-ay bounds y from above, and (x+y)^'=b-x then bounds x+y. The Poincaré-Bendixson theorem gives a periodic orbit from the bounded trajectories away from the repeller.


See also

Equilibrium Point, Limit Cycle, Mass-Action System, Oregonator

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References

Das, T. and Acharyya, M. "Transient Behavior Towards the Stable Limit Cycle in the Sel'kov Model of Glycolysis: A Physiological Disorder." Physica A 567, 125684, 2021. https://doi.org/10.1016/j.physa.2020.125684.Sel'kov, E. E. "Self-Oscillations in Glycolysis 1. A Simple Kinetic Model." Eur. J. Biochem. 4, 79-86, 1968. https://doi.org/10.1111/j.1432-1033.1968.tb00175.x.

Cite this as:

Weisstein, Eric W. "Sel'kov Model." From MathWorld--A Wolfram Resource. https://mathworld.wolfram.com/SelkovModel.html

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