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Morris-Lecar Model


The Morris-Lecar model is a conductance-based dynamical system for electrical oscillations in an excitable membrane (Morris and Lecar 1981). In its planar form, the calcium gate is set to its instantaneous equilibrium value. The remaining variables are the membrane voltage V and the fraction w of open potassium channels. The ordinary differential equations are

CV^'=I-g_L(V-V_L)-g_(Ca)m_infty(V)(V-V_(Ca))-g_Kw(V-V_K)
(1)
w^'=phicosh((V-V_3)/(2V_4))[w_infty(V)-w],
(2)

where V(t) and w(t) are functions of time and primes denote derivatives with respect to t. The constant C>0 is capacitance, I is applied current, and g_j and V_j are the maximal conductance and reversal potential for the leak, calcium, and potassium terms. The gate functions are

m_infty(V)=(1+tanh((V-V_1)/(V_2)))/2
(3)
w_infty(V)=(1+tanh((V-V_3)/(V_4)))/2,
(4)

where V_1 and V_3 are the half-activation voltages, V_2 and V_4 are nonzero voltage scales, and phi>0 sets the potassium gate rate. The w-nullcline is w=w_infty(V). Since 0<w_infty(V)<1, the interval [0,1] is invariant for the gate.

For example, take C=20, I=90, g_L=2, g_(Ca)=4.4, g_K=8, V_L=-60, V_(Ca)=120, V_K=-84, V_1=-1.2, V_2=18, V_3=2, V_4=30, and phi=0.04. Numerical integration from the initial state (V,w)=(-60,0) shows approach to a periodic orbit. The planar model allows the onset of oscillations to be studied through intersections of its nullclines and changes in the stability of the resulting equilibria (Morris and Lecar 1981).


See also

Fitzhugh-Nagumo Equations, Hodgkin-Huxley Equations, Limit Cycle, Nullcline

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References

Morris, C. and Lecar, H. "Voltage Oscillations in the Barnacle Giant Muscle Fiber." Biophys. J. 35, 193-213, 1981. https://doi.org/10.1016/S0006-3495(81)84782-0.

Cite this as:

Weisstein, Eric W. "Morris-Lecar Model." From MathWorld--A Wolfram Resource. https://mathworld.wolfram.com/Morris-LecarModel.html

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