Define a Bouniakowsky polynomial as an irreducible polynomial 
 with integer coefficients, degree 
, and 
. The Bouniakowsky conjecture states that
 
 is prime for an infinite number of integers 
 (Bouniakowsky 1857). As an example of the greatest
 common divisor caveat, the polynomial 
 is irreducible, but always divisible by 2.
Irreducible degree 1 polynomials () always generate an infinite number of primes by Dirichlet's
 theorem. The existence of a Bouniakowsky polynomial that can produce an infinitude
 of primes is undetermined. The weaker fifth Hardy-Littlewood
 conjecture asserts that 
 is prime for an infinite number of integers 
.
Various prime-generating polynomials are known, but none of these always generates a prime (Legendre).
Worse yet, it is unknown if a general Bouniakowsky polynomial will always produce at least 1 prime number. For example,  produces no primes until 
, 764400, 933660, ... (OEIS A122131).