A main effect is the effect of one factor in a factorial experiment after averaging over the levels of the other factors. For two factors
and
with cell means
, the main effect of changing
from level
to level
can be expressed, under equal weighting, as
Different weighting conventions can be needed in unbalanced designs.
A main effect summarizes an average comparison and can conceal an interaction. If the effect of
varies strongly with the level of
, the factor-level comparisons and the interaction are generally
more informative than the main effect alone.