While many computations admit shortcuts that allow them to be performed more rapidly, others cannot be sped up. Computations that cannot
be sped up by means of any shortcut are called computationally irreducible. The principle
of computational irreducibility says that the only way to determine the answer to
a computationally irreducible question is to perform, or simulate, the computation.
Some irreducible computations can be sped up by performing them on faster hardware,
as the principle refers only to computation time.

According to Wolfram (2002, p. 741), if the behavior of a system is obviously simple--and is say either repetitive or
nested--then it will always be computationally reducible. But it follows from the
principle of computational equivalence
that in practically all other cases it will be computationally irreducible. Here,
"practically all" refers to cases that arise naturally or from a simple
rule system as opposed to cases that are constructed artificially such as the examples
given by Wolfram (2002, p. 747).

Israeli and Goldenfeld (2004) have shown that some computationally irreducible elementary cellular automata have properties
that are predictable, and so these properties are computationally
reducible. In particular, these cellular automata can emulate reducible cellular
automata by coarse-graining. One of those is rule 110,
which is a universal cellular automaton.

However, as noted by Wolfram (2002, p. 745), "when the underlying rules are simple there is often still some superficial
computational reducibility.... For example, in the rule 30
pattern on the right one can tell whether a cell at a given position has any chance
of not being white just by doing a short computation that tests whether that position
lies outside the center triangular region of the pattern. And in a class 4 cellular
automaton such as rule 110 one can readily shortcut the
process of evolution at least for a limited number of steps in places where there
happen to be only a few well-separated localized structures present."

Israeli, N. and Goldenfeld, N. "Computational Irreducibility and the Predictability of Complex Physical Systems." Phys. Rev. Lett.92,
074105, 2004.Wolfram, S. A
New Kind of Science. Champaign, IL: Wolfram Media, pp. 737-750, 2002.